Blar i forfatter "Pejler, Gunnar"

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    • Obesity Is Associated with Distorted Proteoglycan Expression in Adipose Tissue 

      Meen, Astri Jeanette; Doncheva, Atanaska Ivanova; Böttcher, Yvonne; Dankel, Simon N; Hoffmann, Anne; Blüher, Matthias; Fernø, Johan; Mellgren, Gunnar; Ghosh, Adhideb; Sun, Wenfei; Dong, Hua; Noé, Falko; Wolfrum, Christian; Pejler, Gunnar; Dalen, Knut Tomas; Kolset, Svein Olav (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-07)
      Proteoglycans are central components of the extracellular matrix (ECM) and binding partners for inflammatory chemokines. Morphological differences in the ECM and increased inflammation are prominent features of the white adipose tissues in patients with obesity. The impact of obesity and weight loss on the expression of specific proteoglycans in adipose tissue is not well known. This study aimed to ...

    • Serglycin Is a Major Proteoglycan in Polarized Human Endothelial Cells and Is Implicated in the Secretion of the Chemokine GRO alpha/CXCL1 

      Meen, Astri Jeanette; Øynebråten, Inger; Reine, Trine M.; Duelli, Annette; Svennevig, Katja Christiane; Pejler, Gunnar; Jenssen, Trond Geir; Kolset, Svein Olav (Journal article; Tidsskriftartikkel; Peer reviewed, 2011-01-28)
      Proteoglycan (PG) expression was studied in primary human umbilical vein endothelial cells (HUVEC). RT-PCR analyses showed that the expression of the PG serglycin core protein was much higher than that of the extracellular matrix PG decorin and the cell surface PG syndecan-1. PG biosynthesis was further studied by biosynthetic [<sup>35</sup>S]sulfate labeling of polarized HUVEC. Interestingly, ...